RIKEN Center for Biosystems Dynamics Research

Peer reviewed articles

41. Sada, T.ย and Kimura, W.: Transition from fetal to postnatal state in the heart: Crosstalk between metabolism and regeneration. Dev.ย Growth Differ.ย in press; PMID: 39463005 DOI: 10.1111/dgd.12947 (review article) ๐Ÿ“–
40.Saito, Y., Sugiura, Y., Sakaguchi, A., Sada, T., Nishiyama, C., Maeda, R., Kaneko, M., Kiyonari, H. and Kimura, W.:ย Postnatal xanthine metabolism regulates cardiac regeneration in mammals. Redox Biol. 79: 103442 (2025) doi: 10.1016/j.redox.2024.103442ย ๐Ÿ“–,ย bioRxiv 2024.07.24.605040; ย doi:10.1101/2024.07.24.605040 ๐Ÿ“–
39. Xiao, F., Nguyen, N., Wang, P., Li, S., Thet, S., Kimura, W., Luo, X., Lam, N., ElHelaly, W. Singh, R., Hsu, C., Ladha, F., Kanchwala, M., Hill, J., Menendez-Montes, I., Cardoso, A., Helena Pereira, A., Xing, C., Hajjar, R., Sadayappan, S., Hinson, J., and Sadek H. A.: Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis. Circulation 2024 Sep 3;150(10):791-805. doi: 10.1161/CIRCULATIONAHA.122.059102,ย  ๐Ÿ“–
38.ย Nishiyama, C., Saito, Y., Sakaguchi, A., Kaneko, M., Kiyonari, H., Xu, Y., Arima, Y., Uosaki, H. and Kimura, W.:ย Prolonged Myocardial Regenerative Capacity in Neonatal Opossum.ย Circulation 146, 125-139 (2022), PMID: 35616010, DOI: 10.1161/CIRCULATIONAHA.121.055269ย ๐Ÿ“–
Press release (Japanese):ย ๅ“บไนณ้กžๆœ€้•ทใฎๅฟƒ่‡“ๅ†็”Ÿๅฏ่ƒฝๆœŸ้–“ใ‚’ๆŒใคใ‚ชใƒใƒƒใ‚ตใƒ  | ็†ๅŒ–ๅญฆ็ ”็ฉถๆ‰€
Asahi newspaper (Japanese):ย ใ€Œๅ“บไนณ้กžๆœ€้•ทใ€ใฎๅ†็”Ÿ่ƒฝๅŠ›ใ€€ๆœชๆˆ็†Ÿใฎใ‚ชใƒใƒƒใ‚ตใƒ ใงใ‚ใ‹ใฃใŸๅฟƒ่‡“ใฎ็ง˜ๅฏ†
Press release (English):ย Harnessing the heart regeneration ability of marsupials | RIKEN
Blog post from RIKEN IAD (English):ย Marsupial heart regeneration ability given to mice
RIKEN English YouTube channel (English):ย Opossum hearts hint at new ways of fighting cardiovascular disease
37. Sakaguchi, A., Kawasaki, M.,ย Saito, Y., Murata, K., Masumoto, H. and Kimura, W.:ย Benzyl isothiocyanate induces cardiomyocyte proliferation and heart regeneration.ย bioRxiv 2021.09.08.459197ย doi:https://doi.org/10.1101/2021.09.08.459197 ๐Ÿ“–
36. Kawakami, S., Yoshitane, H., Morimura, T., Kimura, W. and Fukada, Y.ย :ย Diurnal shift of mouse activity by the deficiency of an ageing-related gene Lmna.ย J. Biochem.171, 509-518 (2022),ย PMID: 35137145 DOI: 10.1093/jb/mvac015 ๐Ÿ“–
35. Saito, Y.ย and Kimura, W.:ย Roles of phase separation for cellular redox maintenance,ย Front. Genet. 12, 691946 (2021), DOI:ย 10.3389/fgene.2021.691946 (review article)ย ๐Ÿ“–
34. Sakaguchi, A. andย Kimura, W.: Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics, Curr. Opin. Genet. Dev. 70, 54-60 (2021), DOI:10.1016/j.gde.2021.05.009 (review article)ย ๐Ÿ“–
33. Iwasa, N., Matsui, T. K., Iguchi, N., Kinugawa, K., Morikawa, N., Sakaguchi, Y. M., Shiota, T., Kobashigawa, S., Nakanishi, M., Matsubayashi, M., Eura, N., Kiriyama, T., Izumi, T., Saito, K., Kataoka, H., Saito, Y., Kimura, W., Nishimura, Y., Mori, E., Sugie, K.: Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation. Front. Cellย Neurosci. 15, 605030 (2021) DOI: 10.3389/fncel.2021.605030 ๐Ÿ“–
32. Sakaguchi, A., Nishiyama C. and Kimura, W.: Cardiac Regeneration as an Environmental Adaptation. Biochim. Biophys. Acta Mol. Cell Res. 1867(4):118623 (2020). PMID: 31837984 DOI: 10.1016/j.bbamcr.2019.118623 (review article)ย ๐Ÿ“–
31. Kimura, W., Nakada, Y. and Sadek, H. A.: Hypoxia Induced Myocardial Regeneration. J. Appl. Physiol. 123, 1676-1681 (2017), DOI: 10.1152/japplphysiol.00328.2017 (review article)ย ๐Ÿ“–
30. Nakada, Y., Canseco, D. C., Thet S., Abdisalaam S., Asaithaymby A., Santos C. X., Shah A., Zhang, H., Faber, J. E., Kinter M. T., Szweda, L. I., Xing, C., Deberardinis, R., Oz O., Lu Z., Zhang C. C., #Kimura, W. and #Sadek, H. A.: Hypoxia induces heart regeneration in adult mice. Nature 541, 222-227 (2017) PMID: 27798600 DOI: 10.1038/nature20173 #Co-corresponding author ๐Ÿ“–
29. Mani, R. S., Amin, M. A., Li, X., Kalyana-Sundaram, S., Veeneman, B. A., Wang, L., Ghosh, A., Aslam, A., Ramanand, S. G., Rabquer, B. J., Kimura W., Tran, M., Cao, X., Roychowdhury, S., Dhanasekaran, S. M., Palanisamy, N., Sadek, H. A., Kapur, P., Koch, A. E., and Chinnaiyan, A. M.: Inflammation induced oxidative stress mediates gene fusion formation in prostate cancer. Cell Rep. 17, 2620-2631 (2016) PMID: 27926866 PMCID: PMC5147555 DOI: 10.1016/j.celrep.2016.11.019 ๐Ÿ“–
28. Koizumi A., Sasano T., Kimura W., Miyamoto Y., Aiba T., Ishikawa T., Nogami A., Fukamizu S., Sakurada H., Takahashi Y., Nakamura H., Ishikura T., Koseki H., Arimura T., Kimura A., Hirao K., Isobe M., Shimizu W., Miura N., Furukawa T.: Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur.ย Heart J. 37, 1469-1475 (2016), PMID: 26429810, PMCID: PMC4914882, DOI: 10.1093/eurheartj/ehv449 ๐Ÿ“–
27. Kimura, W., Muralidhar, S. and Thet, S.: Minor contribution of cardiac progenitor cells in neonatal heart regeneration. Etiology and Morphogenesis of Congenital Heart Disease pp349-351 (2015),PMID:ย 29787132, DOI: 10.1007/978-4-431-54628-3_50 (book chapter)๐Ÿ“–
26. Sabine, A., Bovay, E., Demir C. S., Kimura, W., Jaquet, M., Agalarov, Y., Zangger, N., Scallan, J. P., Graber, W., Gulpinar, E., Kwak, B. R., Mรคkinen, T., Martinez-Corral, I., Ortega, S., Delorenzi, M., Kiefer, F., Davis, M. J., Djonov, V., Miura, N. and Petrova, T. V.: FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J. Clin. Invest. 125, 3861-3877 (2015), PMID: 26389677, PMCID: PMC4607114, DOI: 10.1172/JCI80454 ๐Ÿ“–
25. Ddin, M. K., Kimura, W., Ishikura, T., Koseki, H., Yoshida, N., Islam, M. J., Amin, M. B., Nakamura, K., Wu Y. X., Sato, E., Aoto, K. and Miura, N.: Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodeling and ventricular septum formation. Biomed. Res. 36, 235-245 (2015), PMID: 26299482, DOI: 10.2220/biomedres.36.235 ๐Ÿ“–
24. Kocabas, F., Xie, L., Xie, J., Yu, Z., DeBerardinis, R., Kimura, W., Thet, S., Elshamy, A. F., Abouellail, H., Muralidhar, S., Liu, X., Chen, C., Sadek, H. A., Zhang, C. C. and Zheng, J.: Hypoxic metabolism in human hematopoietic stem cells. Cell Biosci. 5: 39 (2015), PMID: 26221532, PMCID: PMC4517642, DOI: 10.1186/s13578-015-0020-3 ๐Ÿ“–
23. Nakada, Y., Kimura, W. and Sadek, H. A.: Defining The Limit of Embryonic Heart Regeneration. Circulation 132, 77-78 (2015), PMID: 26169647, DOI: 10.1161/CIRCULATIONAHA.115.017070 (review article)๐Ÿ“–
22. Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C. C. and Sadek, H. A.: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature 523, 226-230 (2015), PMID: 26098368, DOI: 10.1038/nature14582๐Ÿ“–
21. Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby. A., Mammen, P. P. and Sadek, H. A.: Human ventricular unloading induces cardiomyocyte proliferation. J. Am. Coll. Cardiol. 65, 892-900 (2015), PMID: 25618530, PMCID: PMC4488905, DOI: 10.1016/j.jacc.2014.12.027๐Ÿ“–
20. Xiao, F., Kimura, W.ย and Sadek, H. A.: A Hippo โ€œAKTโ€ regulates cardiomyocyte proliferation. Circ. Res. 116, 3-15 (2015), PMID: 25552685, PMCID: PMC4467880, DOI: 10.1161/CIRCRESAHA.114.305325 (review article)๐Ÿ“–
19. Kimura, W., Muralidhar, S., Canseco, D. C., Puente, B., Zhang, C. C, Xiao, F., Abderrahman Y. H. and Sadek, H.A: Redox signaling and cardiac renewal. Antioxid. Redox Signal. 21, 1660-1678 (2014), PMID: 25000143, PMCID: PMC4175032, DOI: 10.1089/ars.2014.6029 (review article)๐Ÿ“–
18. *Puente, B. N., *Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M., Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. and Sadek, H. A.: The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response. Cell 157, 565-579 (2014), PMID: 24766806, PMCID: PMC4104514, DOI: 10.1016/j.cell.2014.03.032ย *Co-first author ๐Ÿ“–
17. Mahmoud, A. I., Porrello, E. R., Kimura, W., Olson, E. N. and Sadek, H. A.: Surgical models for cardiac regeneration in neonatal mice. Nat. Protoc. 9, 305-311 (2014), PMID: 24434799, PMCID: PMC3977725, DOI: 10.1038/nprot.2014.021 ๐Ÿ“–
16. Mahmoud, A. I., Kocabas, F., Muralidhar, S. A., Kimura, W., Koura, A. S., Thet, S., Porrello, E. R. and Sadek, H. A.: Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 497, 249-253 (2013), PMID: 23594737, PMCID: PMC4159712, DOI: 10.1038/nature12054 ๐Ÿ“–
15. Wu, Y. X., Sato, E., Kimura, W. and Miura, N.: Baicalin and Scutellarin are proteasome inhibitors that specifically target chymotrypsin-like catalytic activity. Phytother. Res. 27, 1362-1367 (2013), PMID: 23147714, DOI: 10.1002/ptr.4878 ๐Ÿ“–
14. Kimura, W., Sharkar, M. T., Sultana, N., Islam, M. J., Uezato, T. and Miura, N.: Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium. Transgenic Res. 22, 659-666 (2013), PMID: 23117587, DOI: 10.1007/s11248-012-9664-5๐Ÿ“–
13.Kimura, W. and Sadek, H. A.: The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors. Cardiovasc. Diagn. Ther. 2, 278-289 (2012), PMID: 24282728, PMCID: PMC3839158, DOI: 10.3978/j.issn.2223-3652.2012.12.02 (review article)๐Ÿ“–
12. Okano, J., Kimura, W., Papaionnou, V. E., Miura, N., Yamada, G., Shiota, K. and Sakai, Y.: The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev. Dyn. 241, 1744-1756 (2012), PMID: 22972661, DOI: 10.1002/dvdy.23862๐Ÿ“–
11. Wang, B., Hikosaka, K., Sultana, N., Sharkar, M. T., Noritake, H., Kimura, W., Wu, Y. X., Kobayashi, Y., Uezato, T. and Miura, N.: Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes. Biochem. Biophys. Res. Commun. 417, 601-606 (2011), PMID: 22182413, DOI: 10.1016/j.bbrc.2011.12.014 ๐Ÿ“–
ย 10. Hikosaka, K., Noritake, H., Kimura, W., Sultana, N., Sharkar, M. T., Tagawa, Y., Uezato, T., Kobayashi, Y., Wakita, T. and Miura, N.: Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry. Biomed. Res. 32, 143-150 (2011), PMID: 21551950 ๐Ÿ“–
9. Kimura, W., Cantas, A., Sheng, G., Jakt, M., Yasugi, S. and Fukuda, K.: Identification of region specific genes in the early chicken endoderm. Gene Expr. Patterns 11, 171-180 (2011), PMID: 21081180, DOI: 10.1016/j.gep.2010.11.002 ๐Ÿ“–
8.ย  Kimura, W., Machii, M., Xue, X., Sultana, N., Hikosaka, K., Sharkar, M. T., Uezato, T., Matsuda, M., Koseki, H. and Miura, N.: Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development. Genesis 49, 2-9 (2011), PMID: 21254332, DOI: 10.1002/dvg.20688 ๐Ÿ“–
7. Yang, Z., Hikosaka, K., Sharkar, M. T., Tamakoshi, T., Chandra, A., Wang, B., Itakura, T., Xue, X., Uezato, T., Kimura, W. and Miura, N.: The mouse forkhead gene Foxp2 modulates expression of the lung genes. Life Sci. 87, 17-25 (2010), PMID: 20553735, DOI: 10.1016/j.lfs.2010.05.009๐Ÿ“–
6. Xue, X., Kimura, W., Wang, B., Hikosaka, K., Itakura, T., Matsuda, M., Koseki, H. and Miura, N.: A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10lacZ allele. Genesis 48, 295-302 (2010), PMID: 20162674, DOI: 10.1002/dvg.20615 ๐Ÿ“–
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