Peer reviewed articles

38. Nishiyama, C., Saito, Y., Sakaguchi, A., Kaneko, M., Kiyonari, H., Xu, Y., Arima, Y., Uosaki, H. and Kimura, W.: Prolonged Myocardial Regenerative Capacity in Neonatal Opossum. Circulation 146, 125-139 (2022), PMID: 35616010, DOI: 10.1161/CIRCULATIONAHA.121.055269 📖

37. Sakaguchi, A., Kawasaki, M., Saito, Y., Murata, K., Masumoto, H. and Kimura, W.: Benzyl isothiocyanate induces cardiomyocyte proliferation and heart regeneration. bioRxiv 2021.09.08.459197 doi:https://doi.org/10.1101/2021.09.08.459197 📖

36. Kawakami, S., Yoshitane, H., Morimura, T., Kimura, W. and Fukada, Y. : Diurnal shift of mouse activity by the deficiency of an ageing-related gene Lmna. J. Biochem.171, 509-518 (2022), PMID: 35137145 DOI: 10.1093/jb/mvac015 📖

35. Saito, Y. and Kimura, W.: Roles of phase separation for cellular redox maintenance, Front. Genet. 12, 691946 (2021), DOI: 10.3389/fgene.2021.691946 (review article) 📖

34. Sakaguchi, A. and Kimura, W.: Metabolic regulation of cardiac regeneration: roles of hypoxia, energy homeostasis, and mitochondrial dynamics, Curr. Opin. Genet. Dev. 70, 54-60 (2021), DOI:10.1016/j.gde.2021.05.009 (review article) 📖

33. Iwasa, N., Matsui, T. K., Iguchi, N., Kinugawa, K., Morikawa, N., Sakaguchi, Y. M., Shiota, T., Kobashigawa, S., Nakanishi, M., Matsubayashi, M., Eura, N., Kiriyama, T., Izumi, T., Saito, K., Kataoka, H., Saito, Y., Kimura, W., Nishimura, Y., Mori, E., Sugie, K.: Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation. Front. Cell Neurosci. 15, 605030 (2021) DOI: 10.3389/fncel.2021.605030 📖

32. Sakaguchi, A., Nishiyama C. and Kimura, W.: Cardiac Regeneration as an Environmental Adaptation. Biochim. Biophys. Acta Mol. Cell Res. 1867(4):118623 (2020). PMID: 31837984 DOI: 10.1016/j.bbamcr.2019.118623 (review article) 📖

31. Kimura, W., Nakada, Y. and Sadek, H. A.: Hypoxia Induced Myocardial Regeneration. J. Appl. Physiol. 123, 1676-1681 (2017), DOI: 10.1152/japplphysiol.00328.2017 (review article) 📖

30. Nakada, Y., Canseco, D. C., Thet S., Abdisalaam S., Asaithaymby A., Santos C. X., Shah A., Zhang, H., Faber, J. E., Kinter M. T., Szweda, L. I., Xing, C., Deberardinis, R., Oz O., Lu Z., Zhang C. C., #Kimura, W. and #Sadek, H. A.: Hypoxia induces heart regeneration in adult mice. Nature 541, 222-227 (2017) PMID: 27798600 DOI: 10.1038/nature20173 #Co-corresponding author 📖

29. Mani, R. S., Amin, M. A., Li, X., Kalyana-Sundaram, S., Veeneman, B. A., Wang, L., Ghosh, A., Aslam, A., Ramanand, S. G., Rabquer, B. J., Kimura W., Tran, M., Cao, X., Roychowdhury, S., Dhanasekaran, S. M., Palanisamy, N., Sadek, H. A., Kapur, P., Koch, A. E., and Chinnaiyan, A. M.: Inflammation induced oxidative stress mediates gene fusion formation in prostate cancer. Cell Rep. 17, 2620-2631 (2016) PMID: 27926866 PMCID: PMC5147555 DOI: 10.1016/j.celrep.2016.11.019 📖

28. Koizumi A., Sasano T., Kimura W., Miyamoto Y., Aiba T., Ishikawa T., Nogami A., Fukamizu S., Sakurada H., Takahashi Y., Nakamura H., Ishikura T., Koseki H., Arimura T., Kimura A., Hirao K., Isobe M., Shimizu W., Miura N., Furukawa T.: Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur. Heart J. 37, 1469-1475 (2016), PMID: 26429810, PMCID: PMC4914882, DOI: 10.1093/eurheartj/ehv449 📖

27. Kimura, W., Muralidhar, S. and Thet, S.: Minor contribution of cardiac progenitor cells in neonatal heart regeneration. Etiology and Morphogenesis of Congenital Heart Disease pp349-351 (2015),PMID: 29787132, DOI: 10.1007/978-4-431-54628-3_50 (book chapter)📖

26. Sabine, A., Bovay, E., Demir C. S., Kimura, W., Jaquet, M., Agalarov, Y., Zangger, N., Scallan, J. P., Graber, W., Gulpinar, E., Kwak, B. R., Mäkinen, T., Martinez-Corral, I., Ortega, S., Delorenzi, M., Kiefer, F., Davis, M. J., Djonov, V., Miura, N. and Petrova, T. V.: FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J. Clin. Invest. 125, 3861-3877 (2015), PMID: 26389677, PMCID: PMC4607114, DOI: 10.1172/JCI80454 📖

25. Ddin, M. K., Kimura, W., Ishikura, T., Koseki, H., Yoshida, N., Islam, M. J., Amin, M. B., Nakamura, K., Wu Y. X., Sato, E., Aoto, K. and Miura, N.: Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodeling and ventricular septum formation. Biomed. Res. 36, 235-245 (2015), PMID: 26299482, DOI: 10.2220/biomedres.36.235 📖

24. Kocabas, F., Xie, L., Xie, J., Yu, Z., DeBerardinis, R., Kimura, W., Thet, S., Elshamy, A. F., Abouellail, H., Muralidhar, S., Liu, X., Chen, C., Sadek, H. A., Zhang, C. C. and Zheng, J.: Hypoxic metabolism in human hematopoietic stem cells. Cell Biosci. 5: 39 (2015), PMID: 26221532, PMCID: PMC4517642, DOI: 10.1186/s13578-015-0020-3 📖

23. Nakada, Y., Kimura, W. and Sadek, H. A.: Defining The Limit of Embryonic Heart Regeneration. Circulation 132, 77-78 (2015), PMID: 26169647, DOI: 10.1161/CIRCULATIONAHA.115.017070 (review article)📖

22. Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C. C. and Sadek, H. A.: Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart. Nature 523, 226-230 (2015), PMID: 26098368, DOI: 10.1038/nature14582📖

21. Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby. A., Mammen, P. P. and Sadek, H. A.: Human ventricular unloading induces cardiomyocyte proliferation. J. Am. Coll. Cardiol. 65, 892-900 (2015), PMID: 25618530, PMCID: PMC4488905, DOI: 10.1016/j.jacc.2014.12.027📖

20. Xiao, F., Kimura, W. and Sadek, H. A.: A Hippo “AKT” regulates cardiomyocyte proliferation. Circ. Res. 116, 3-15 (2015), PMID: 25552685, PMCID: PMC4467880, DOI: 10.1161/CIRCRESAHA.114.305325 (review article)📖

19. Kimura, W., Muralidhar, S., Canseco, D. C., Puente, B., Zhang, C. C, Xiao, F., Abderrahman Y. H. and Sadek, H.A: Redox signaling and cardiac renewal. Antioxid. Redox Signal. 21, 1660-1678 (2014), PMID: 25000143, PMCID: PMC4175032, DOI: 10.1089/ars.2014.6029 (review article)📖

18. *Puente, B. N., *Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M., Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. and Sadek, H. A.: The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response. Cell 157, 565-579 (2014), PMID: 24766806, PMCID: PMC4104514, DOI: 10.1016/j.cell.2014.03.032 *Co-first author 📖

17. Mahmoud, A. I., Porrello, E. R., Kimura, W., Olson, E. N. and Sadek, H. A.: Surgical models for cardiac regeneration in neonatal mice. Nat. Protoc. 9, 305-311 (2014), PMID: 24434799, PMCID: PMC3977725, DOI: 10.1038/nprot.2014.021 📖

16. Mahmoud, A. I., Kocabas, F., Muralidhar, S. A., Kimura, W., Koura, A. S., Thet, S., Porrello, E. R. and Sadek, H. A.: Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 497, 249-253 (2013), PMID: 23594737, PMCID: PMC4159712, DOI: 10.1038/nature12054 📖

15. Wu, Y. X., Sato, E., Kimura, W. and Miura, N.: Baicalin and Scutellarin are proteasome inhibitors that specifically target chymotrypsin-like catalytic activity. Phytother. Res. 27, 1362-1367 (2013), PMID: 23147714, DOI: 10.1002/ptr.4878 📖

14. Kimura, W., Sharkar, M. T., Sultana, N., Islam, M. J., Uezato, T. and Miura, N.: Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium. Transgenic Res. 22, 659-666 (2013), PMID: 23117587, DOI: 10.1007/s11248-012-9664-5📖

13.Kimura, W. and Sadek, H. A.: The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors. Cardiovasc. Diagn. Ther. 2, 278-289 (2012), PMID: 24282728, PMCID: PMC3839158, DOI: 10.3978/j.issn.2223-3652.2012.12.02 (review article)📖

12. Okano, J., Kimura, W., Papaionnou, V. E., Miura, N., Yamada, G., Shiota, K. and Sakai, Y.: The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev. Dyn. 241, 1744-1756 (2012), PMID: 22972661, DOI: 10.1002/dvdy.23862📖

11. Wang, B., Hikosaka, K., Sultana, N., Sharkar, M. T., Noritake, H., Kimura, W., Wu, Y. X., Kobayashi, Y., Uezato, T. and Miura, N.: Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes. Biochem. Biophys. Res. Commun. 417, 601-606 (2011), PMID: 22182413, DOI: 10.1016/j.bbrc.2011.12.014 📖

10. Hikosaka, K., Noritake, H., Kimura, W., Sultana, N., Sharkar, M. T., Tagawa, Y., Uezato, T., Kobayashi, Y., Wakita, T. and Miura, N.: Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry. Biomed. Res. 32, 143-150 (2011), PMID: 21551950 📖

9. Kimura, W., Cantas, A., Sheng, G., Jakt, M., Yasugi, S. and Fukuda, K.: Identification of region specific genes in the early chicken endoderm. Gene Expr. Patterns 11, 171-180 (2011), PMID: 21081180, DOI: 10.1016/j.gep.2010.11.002 📖

8. Kimura, W., Machii, M., Xue, X., Sultana, N., Hikosaka, K., Sharkar, M. T., Uezato, T., Matsuda, M., Koseki, H. and Miura, N.: Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development. Genesis 49, 2-9 (2011), PMID: 21254332, DOI: 10.1002/dvg.20688 📖

7. Yang, Z., Hikosaka, K., Sharkar, M. T., Tamakoshi, T., Chandra, A., Wang, B., Itakura, T., Xue, X., Uezato, T., Kimura, W. and Miura, N.: The mouse forkhead gene Foxp2 modulates expression of the lung genes. Life Sci. 87, 17-25 (2010), PMID: 20553735, DOI: 10.1016/j.lfs.2010.05.009📖

6. Xue, X., Kimura, W., Wang, B., Hikosaka, K., Itakura, T., Matsuda, M., Koseki, H. and Miura, N.: A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10lacZ allele. Genesis 48, 295-302 (2010), PMID: 20162674, DOI: 10.1002/dvg.20615 📖

5. Katsumoto, K., Fukuda, K., Kimura, W., Shimamura, K., Yasugi, S. and Kume, S.: Origin of pancreatic precursors in the chick embryo and the mechanism of endoderm regionalization. Mech. Dev. 126, 539-551 (2009), PMID: 19341795, DOI: 10.1016/j.mod.2009.03.006 📖

4. Itakura, T., Chandra, A., Yang, Z., Xue, X., Wang, B., Kimura, W., Hikosaka, K., Inohara, K., Kudo, A., Uezato, T. and Miura, N.: The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function. J. Biochem. 143, 407-416 (2008), PMID: 18079162, DOI: 10.1093/jb/mvm235 📖

3. Kimura, W., Yasugi, S. and Fukuda, K.: Regional specification of the endoderm in the early chick embryo. Dev. Growth Differ. 49, 365-372 (2007) PMID: 17428263, DOI: 10.1111/j.1440-169X.2007.00933.x📖

2. Kimura, W., Yasugi, S, Stern, C. D. and Fukuda, K.: Fate and plasticity of the endoderm in the early chick embryo. Dev. Biol. 289, 283-295 (2006)PMID: 16337933 DOI: 10.1016/j.ydbio.2005.09.009 📖

1. Hojo, M., Takada, I, Kimura, W., Fukuda, K. and Yasugi, S.: Expression patterns of the chicken peroxisome proliferator-activated receptors (PPARs) during the development of the digestive organs. Gene Expr. Patterns 6, 171-179 (2006), PMID: 16325478, DOI: 10.1016/j.modgep.2005.06.009 📖

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